lidocaine half life

The elimination half life of prilocaine is approximately 10 to 150 minutes mean 70 48 sd n 13. Lidocaine is similar to bupivacaine and procaine. Less if chf shock digoxin toxicity geriatric excretion.

The systemic clearance is 18 to 64 ml min kg mean 38 15 sd n 13.

Lidocaine half life. How does lidocaine injection work. The elimination half life of lidocaine hydrochloride following an intravenous bolus injection is typically 1 5 to 2 hours. Lidocaine is a synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. Because of the rapid rate at which lidocaine hcl is metabolized any condition that affects liver function may alter lidocaine hcl kinetics.

Initially lidocaine has a half life of 7 30 minutes as drug distributes into body tissues. The terminal half life may be up to 8 hours in patients with hepatic failure. Renal dysfunction does not affect lidocaine kinetics but may increase the accumulation of metabolites. The half life may be prolonged two fold or more in patients with liver dysfunction.

The elimination half life of lidocaine hcl following an intravenous bolus injection is typically 1 5 to 2 hours. Less than 10 of lidocaine is excreted unchanged. Packaging 25 100 g in poly bottle. 2 5 8 hr parent drug megx 2 hr and gx 10 hr metabolites.

Approximately 90 of lidocaine hydrochloride administered is excreted in the form of various metabolites and less than 10 is excreted unchanged. The half life may be prolonged two fold or more in patients with liver dysfunction. Lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltage gated sodium channels thereby inhibiting the ionic fluxes required for the initiation and conduction of impulses and effecting local anesthesia. Lidocaine should be stored at room temperature between 15 c to 30 c 59 f to 86 f.

Half life prolonged with chf or liver disease clearance. Factors such as acidosis and the use of cns stimulants and depressants affect the cns levels of lidocaine required to produce overt systemic effects. This reflects saturation of the tissues and elimination of drug by the liver and kidneys. Application lidocaine may be used for drug testing and for voltage clamp experiments.

During intravenous studies the elimination half life of lidocaine was statistically significantly longer in elderly patients 2 5 hours than in younger patients 1 5 hours. The half life of lidocaine elimination from the plasma following iv administration is 81 to 149 minutes mean 107 22 sd n 15. Lidocaine like other local anesthetics causes a loss of sensation by reducing the flow of sodium in and out nerves to decrease the initiation and transfer of nerve signals. Eventually the half life increases to 1 5 3 hours.

Lidocaine and its metabolites are excreted by the kidneys. The primary metabolite in urine is a conjugate of 4 hydroxy 2 6 dimethylaniline.

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